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The Born cross sections and effective form factors for process e+e−→Ξ−Ξ¯+ are measured at eight center-of-mass energies between 2.644 3.080 GeV, using a total integrated luminosity of 363.9 pb−1 e+e− collision data collected with the BESIII detector BEPCII. After performing fit to section e+e−→Ξ−Ξ¯+, no significant threshold effect is observed.Received 19 October 2020Accepted 11 December 2020DOI:https://doi.org/10.1103/PhysRevD.103.012005Published by American Physical Society under terms Creative Commons Attribution 4.0 International license. Further distribution this work must maintain attribution author(s) published article’s title, journal citation, DOI. Funded SCOAP3.Published SocietyPhysics Subject Headings (PhySH)Research AreasQuantum chromodynamicsPhysical SystemsHyperonsPropertiesForm factorsTechniquesElectromagnetic calorimetersLepton collidersParticles & Fields